{"id":7345,"date":"2026-02-02T08:46:42","date_gmt":"2026-02-02T13:46:42","guid":{"rendered":"https:\/\/canadabiznews.ca\/press-releases\/pr\/advancell-and-48hour-discovery-enter-exclusive-agreement-to-advance-a-lead-212-radioligand-therapy-program\/"},"modified":"2026-02-02T08:46:42","modified_gmt":"2026-02-02T13:46:42","slug":"advancell-and-48hour-discovery-enter-exclusive-agreement-to-advance-a-lead-212-radioligand-therapy-program","status":"publish","type":"press-releases","link":"https:\/\/canadabiznews.ca\/press-releases\/pr\/advancell-and-48hour-discovery-enter-exclusive-agreement-to-advance-a-lead-212-radioligand-therapy-program\/","title":{"rendered":"AdvanCell and 48Hour Discovery Enter Exclusive Agreement to Advance a Lead-212 Radioligand Therapy Program"},"content":{"rendered":"
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AdvanCell and 48Hour Discovery Announce Collaboration and Exclusive Licensing Agreement to Develop a Lead-212 Alpha Radioligand Therapy Program<\/i><\/p>\n

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We see this program as an important validation of our discovery engine in the radioligand therapy space.\u201d<\/b>\n
\u2014 Rick Finnegan, CEO of 48Hour Discovery<\/div>\n<\/div>\n

EDMONTON, ALBERTA, CANADA, February 2, 2026 \/EINPresswire.com<\/a>\/ — AdvanCell<\/a>, a clinical-stage radiopharmaceutical company developing innovative targeted alpha therapies for cancer, and 48Hour Discovery<\/a>, a peptide discovery platform company, today announced a collaboration and exclusive licensing agreement to develop a novel peptide-based Lead-212 (\u00b2\u00b9\u00b2Pb) radioligand therapy program for oncology.<\/p>\n

The collaboration is focused on the development of a purpose-built \u00b2\u00b9\u00b2Pb-targeted radioligand therapy, including a peptide ligand optimized for delivery of AdvanCell\u2019s lead-212 (\u00b2\u00b9\u00b2Pb) alpha-emitting payload. While centered on a 212Pb targeted RLT, the work also serves as a proof point for the broader applicability of 48Hour Discovery\u2019s peptide discovery engine in radioligand therapy (RLT) development, demonstrating its ability to generate ligands compatible with targeted alpha delivery.<\/p>\n

Precision Alpha Therapy, Enabled by Rapid Peptide Discovery
\nLead-212 is a potent alpha-emitting radionuclide that enables localized, high-energy radiation delivery while minimizing damage to surrounding healthy tissue. AdvanCell has built an integrated platform around \u00b2\u00b9\u00b2Pb spanning isotope supply, manufacturing, and clinical development.
\n48Hour Discovery\u2019s platform\u2014combining large phage display libraries, high-throughput screening, and AI and chemical optimization\u2014has been designed to rapidly generate peptides with high affinity and specificity. This program highlights the platform\u2019s capacity to meet the stringent requirements of RLT development, including selectivity, PK and biodistribution properties, stability and payload compatibility.<\/p>\n

\u201cThis collaboration reflects the strength of our \u00b2\u00b9\u00b2Pb platform and our ambition to translate scientific innovation into novel targeted alpha therapies that can meaningfully change outcomes for patients,\u201d said Philina Lee, PhD, CEO of AdvanCell. \u201cIt also demonstrates how innovative discovery technologies can be applied to accelerate the development of highly targeted alpha therapies.\u201d<\/p>\n

Rick Finnegan, CEO of 48Hour Discovery, added:
\n\u201cWe see this program as an important validation of our discovery engine in the radioligand therapy space. It underscores the broader utility of our platform for generating ligands suited to demanding oncology applications. Importantly, this agreement is one of several partnerships we have entered into recently with companies developing radioligand therapies, and together they highlight the versatility of our platform across this rapidly growing modality.\u201d<\/p>\n

About 48Hour Discovery<\/p>\n

48Hour Discovery, headquartered in Edmonton, is a pioneering biotechnology company that specializes in rapid drug discovery through its revolutionary peptide platform. By harnessing state-of-the-art technologies, the company quickly identifies and optimizes drug candidates providing an innovative approach to tackling unmet medical needs. Founded in 2017, 48Hour Discovery has validated its technology through strategic partnerships with over 25 companies, including global pharmaceutical leaders. Discover more about our groundbreaking initiatives at www.48hourdiscovery.com<\/a>.<\/p>\n

Rick Finnegan
\n48Hour Discovery
\nemail us here<\/a>
\nVisit us on social media:
\nLinkedIn<\/a><\/p>\n

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<\/p>","protected":false},"excerpt":{"rendered":"

AdvanCell and 48Hour Discovery Announce Collaboration and Exclusive Licensing Agreement to Develop a Lead-212 Alpha Radioligand Therapy Program We see this program as an important validation of our discovery engine in the radioligand therapy space.\u201d \u2014 Rick Finnegan, CEO of 48Hour Discovery EDMONTON, ALBERTA, CANADA, February 2, 2026 \/EINPresswire.com\/ — AdvanCell, a clinical-stage radiopharmaceutical company … Read more<\/a><\/p>\n","protected":false},"featured_media":7346,"template":"","class_list":["post-7345","press-releases","type-press-releases","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/canadabiznews.ca\/press-releases\/wp-json\/wp\/v2\/press-releases\/7345","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/canadabiznews.ca\/press-releases\/wp-json\/wp\/v2\/press-releases"}],"about":[{"href":"https:\/\/canadabiznews.ca\/press-releases\/wp-json\/wp\/v2\/types\/press-releases"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/canadabiznews.ca\/press-releases\/wp-json\/wp\/v2\/media\/7346"}],"wp:attachment":[{"href":"https:\/\/canadabiznews.ca\/press-releases\/wp-json\/wp\/v2\/media?parent=7345"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}